EPAS1 and hereditary clear cell renal cell carcinoma: Four DE miRNAs (ssc-miR-210, ssc-miR-1343, ssc-miR-142-5p, and ssc-miR-421-5p) that are involved in the renal cell carcinoma pathway were upregulated in TPs, and the corresponding target genes were EPAS1, EGLN3, EGLN1, and VEGFC. Both EPAS1 and EGLN1 are closely associated with the high-altitude adaptation of Tibetan populations [37], and are involved in hypoxia pathways as key regulators during chronic hypoxia [52].