Since the development of monoclonal antibodies and inhibitors targeting the vascular endothelial growth factor A (Ranibizumab, Bevacizumab and Aflibercept), effective treatments applied by intravitreal injections are available.[3] The MARINA, ANCHOR and the VIEW1 and 2 studies are regarded as the cornerstone studies in the use the Anti VEGF-A agents in W-AMD and demonstrated that the decline of visual acuity caused by W-AMD can not only be delayed or halted but even reversed and clinically relevant gains of visual acuity can be achieved.[4–6]. This evidence concerns the gene VEGFA and age-related macular degeneration.