ARID1A and neoplasm: Significantly, a single intraperitoneal injection of DEN increased tumor incidence and the number of macroscopic tumor nodules on the liver surface of Arid1aLKO mice at the ninth months after DEN administration as compared to Arid1af/f littermates (Fig 3A–3C), revealing that Arid1a deficiency enhances DEN-induced hepatocarcinogenesis.