Base on this, we constructed conditional hepatocyte-specific Arid1a knockout (KO) (Arid1aLKO) mice to explore its roles in HCC development by crossing mice carrying loxP-flanked Arid1a exon 8 alleles (Arid1af/f) with Alb-Cre transgenic mice, resulting in efficient Cre-mediated recombination in hepatocytes (S1A Fig). Here, ALB is linked to hepatocellular carcinoma.