It has been shown that the interference with the binding of CD44 expressed on tumor cells to HA using either the soluble CD44 ectodomain as a competitor or antibodies that specifically block the binding of HA to CD44, impaired tumor growth and metastasis in breast cancer cells [83,84], while HA oligosaccharides had similar effects in inhibiting tumor growth in vivo [84]. Here, CD44 is linked to breast cancer.