A recent report has shown a surprising example of the interrelationship between different antioxidant proteins in mouse colon cancer cells, wherein the downregulation of either the 15kDa selenoprotein or TXNRD1 resulted in the reversal of several malignant properties to those more like normal cells; however, the double knockdown of both proteins reversed the anti-malignant properties rendering the cells with additional cancer properties [68]. Here, SELENOS is linked to colonic neoplasm.