CD represents a unique model of autoimmune disease as, in contrast to other autoimmune diseases, the triggering environmental factor (gluten), a close genetic association with human leukocyte antigen (HLA) genes (DQ2 or DQ8), and a highly specific humoral autoimmune response (autoantibodies to tissue transglutaminase) are known [1]. This evidence concerns the gene TGM2 and autoimmune disease.