ROBO1 and type 2 diabetes mellitus: Other signals were at or near UBE2E2 (ubiquitin-conjugating enzyme E2E 2), a gene that has been associated with risk to gestational and type 2 diabetes [71–73], ICK (intestinal cell [MAK-like] kinase), and ROBO1 (roundabout, axon guidance receptor, homolog 1), which encodes a member of the immunoglobulin gene superfamily and plays a role in axon guidance and neuronal precursor cell migration (Table 2).