As shown in the IMGT/HLA database (http://www.ebi.ac.uk/imgt/hla), over 40 polymorphic alleles have been found in exon 2 to 6 of MICB. Specific polymorphisms are associated with autoimmune diseases, cancer, and infectious diseases, as well as with the success of hematopoietic stem cell transplantation. This evidence concerns the gene MICB and autoimmune disease.