In the context of viral infections, Qin et al. [130] observed that a simultaneous antagonism of CCR4 by increased CXCR3 ligand expression (CXCL11) and loss of CCR4 ligand expression contributed to reducing homing of FoxP3+ Treg cells to lymph node and intestinal tissues during SIV infection. Here, CCR4 is linked to viral infectious disease.