KMT2A and cancer: Cancer cells convert glucose into lactate via aerobic glycolysis (termed the ‘Warburg effect’) to meet energetic demands and support proliferation.34 To test whether increased proliferation was accompanied by a shift toward glycolytic metabolism, we analyzed the oxygen consumption rate (OCR) and lactate production (extracellular acidification rate; ECAR) of the MLL–ENL cell lines using the Seahorse analyzer.