Factors, other than renewal crisis, implicated in β-cell death in type 2 diabetes include glucolipotoxicity, amyloid deposits in pancreatic islet and high metabolic demand causing oxidative stress, endoplasmic reticulum stress as well as inflammatory signals such as cytokines production in the islet insulin producing cells have been associated with β-cell death in type 2 diabetes [2]. The gene discussed is INS; the disease is type 2 diabetes mellitus.