Premature ovarian failure (POF) is a term to define the women younger than 40 years of age who present with amenorrhea lasting more than 4 months and hypoestrogenic-hypergonadotropic serum profile (follicle stimulating hormone (FSH) levels≥ 40 mIU/mL on two occasions) (1-5). Here, BRD2 is linked to premature menopause.