In conclusion, the results of the REALISTIC study conducted in patients reflective of real-world clinical care demonstrate sustained improvements in disease activity and physical functions following 28 weeks of CZP treatment across this diverse population of RA patients, including with and without prior anti-TNF use, on a variety of concomitant DMARDs and regardless of disease duration (< and ≥2 years). The gene discussed is TNF; the disease is rheumatoid arthritis.