Of the two independent GWAS, one study with 1,538 cases and 1,465 controls for GWA scan identified the single nucleotide polymorphism (SNP) rs9272105 (located between HLA-DQA1 and HLA-DRB1)5, while the other study with 1,161 HCC cases and 1,353 controls for GWA scan identified the SNP rs9275319 at HLA-DQ6. This evidence concerns the gene HLA-DRB1 and hepatocellular carcinoma.