GSK3B and glomerulosclerosis: To evaluate the effect of podocyte specific knockout of GSK3β on podocyte pathology, we adopted the murine model of protein overload induced glomerular injury, which recapitulates key features of proteinuric glomerulopathy in human chronic kidney disease, including glomerular hyperperfusion, podocyte injury, massive proteinuria, and glomerulosclerosis [23, 24].