JAG2 and acute myeloid leukemia: Sequencing of acute myeloid leukemias (AMLs) revealed that two-thirds of AML cases in which Rabex-5 mRNA is downregulated show upregulation of Notch, Delta or Jagged2 (a mammalian Serrate ortholog) mRNA (Cerami et al., 2012; The Cancer Genome Atlas Research Network, 2013; Gao et al., 2013).