Therapeutic strategies that can suppress Endo180 function in metastatic disease (Fig. 6f), combined with the development of Endo180-targeted diagnostics, could provide the opportunity to make a major advance in the personalized treatment of men with Endo180-positive prostate cancer who are at risk of, or have progressed towards, the development of Endo180-driven bone metastasis [17, 18]. The gene discussed is MRC2; the disease is prostate cancer.