RAC1 and neoplasm: The possible intracellular cues that can direct this Endo180-associated tumor cell plasticity include Cdc42 and Rac1 and the Rho-ROCK-MLC2 pathway, which are activated by the spatiotemporal localization of the Endo180 receptor to the plasma membrane or constitutively recycling endosomes [18, 19, 26].