Under these conditions, AEA (at 10−6 M and 10−8 M) and concomitant FAAH inhibition with JNJ1661010 (1 μM) reduced the production of IL-6 and IL-8 by RA but not OA mixed synoviocytes (Fig. 1b, d). The gene discussed is CXCL8; the disease is rheumatoid arthritis.