No significant differences were detected in the incidence of hypoglycemia between the patients with glinide agents and with other OHAs; however, the incidence of hypoglycemia was significantly higher in patients using SU agents than those using metformin, DPP-4 inhibitors, or α-GIs (P = 0.0257, P = 0.0001, and P = 0.0301, respectively). The gene discussed is DPP4; the disease is Hypoglycemia.