A study by Liu showed that Mg deficiency in sepsis patients promoted the translocation of high mobility group box 1 (HMGB1), an important inflammatory factor that is closely related to mortality, from the nucleus to the cytoplasm and its extracellular secretion in LPS-activated macrophages, while enhancing the expression of HMGB1 mRNA. The gene discussed is HMGB1; the disease is Sepsis.