For HKx31, at 24 and 48 hours post-infection, titres of infectious virus released from BST-2-deficient AEC were significantly reduced compared to WT AEC, although this was not the case for the Brazil/78 or Sol Is/06 IAV strains, where viral release of these strains from AEC occurred independently of BST-2 (Fig 3A). This evidence concerns the gene BST2 and infection.