Seven out of the 13 biomarkers including C5ORF4, COPZ1, MACF1, WLS, PRG3, ZNF160 and EFTUD2, were replicated in blood of PD patients and HC nested in the Harvard Biomarker Study (HBS) with 78% sensitivity and 90% specificity [12]. This evidence concerns the gene MACF1 and Parkinson disease.