PDE4B and T-cell non-Hodgkin lymphoma: This analysis revealed an up-regulation of 6 genes (namely CAV1, CCNB2, ENAH, PSEN2, THY1, TNFRSF21) (Fig 1A) and a down-regulation of 15 genes (namely BCL10, CD3G, CD5, FOXP1, IL23A, ITK, LAT, PAG1, PDE4B, PRKCQ, RICTOR, STAT5A, TNFRSF14, TSC22D3, UBASH3A) (Fig 1B) that were observed to be differentially expressed (p < 0.001, FDR < 0.001) in all T-cell lymphoma subtypes (Table 2).