To this end, we mined the NCBI GEO DataSets (Table 1) for chip-matched, mature T-cell lymphoma samples (n = 187) and healthy CD4+ and CD8+ T-cell controls (n = 52) with focus on genes annotated to function in T-cell receptor signaling, T-cell co-stimulation, T-cell homeostasis, and T-cell differentiation in the gene ontology (GO) directory to mitigate background from the stromal compartment. The gene discussed is CD8A; the disease is T-cell non-Hodgkin lymphoma.