Positive correlation was found between big ET-1 and CACS (r = 0.567,P<0.001), age (r = 0.284,P<0.001), smoking status (r = 0.184,P<0.001), CAD (r = 0.387,P<0.001), DM (r = 0.142,P = 0.001), hypertension (r = 0.100,P = 0.025), HbA1c (r = 0.111,P<0.001) and hs-CRP (r = 0.138, P = 0.002, Table 2). The gene discussed is EDN1; the disease is Hypertension.