Controlled for major potential confounders which p-values are less than 0.05 in the univariate analysis (including age, gender, smoking, CAD, hypertension, TC, HbA1c, hs-CRP) and drugs which may affect plasma big ET-1 level (such as ACEI, ARB and statin), the tertiles of big ET-1 were analysised in the multivariate analysis by Cox regression model (Table 4). This evidence concerns the gene EDN1 and Hypertension.