As for T47D cells, significant cleavage of caspase-3 but not caspase-8 and PARP was found at dosage as low as 10μM following 48 hours treatment (Figure 2B), suggesting simvastatin-induced apoptosis was more caspase-3 dependent in a subpopulation of breast cancer cells. Here, CASP8 is linked to breast carcinoma.