PTPN6 and anaplastic large cell lymphoma: Our findings, however, suggest that binding between PTPN6 and STAT3 does not exist and these data come in contrast with a previous hypothesis by Paling et al. [44] Han et al. [45] demonstrated that loss of PTPN6 enhances JAK3/STAT3 interaction in ALK + anaplastic large-cell lymphoma.