The oncogenicity induced in glioma cells by low HOXB1 expression was not only reversed by an miR-3175 inhibitor, evident as reduced cell proliferation and increased cell apoptosis, but the expression of several apoptosis-related proteins was affected by low HOXB1, including that of procaspase-3, p53, and cytochrome c. This evidence concerns the gene HOXB1 and central nervous system cancer.