We found that BaP or CXCL13 treatment or SPP1 overexpression in lung epithelial or cancer cells did not up-regulate RANKL or Src (data not shown), but did activate β–catenin (Figure 6—figure supplement 1), suggesting that CXCL13 may induce an EMT via different mechanisms in different settings. This evidence concerns the gene SPP1 and cancer.