BCL2 and neoplasm: Loss of MCL-1 function through gene silencing or indirect pharmacological inhibition sensitizes many tumor types to navitoclax.24, 25, 26, 27, 28 A-1210477 is a MCL-1-specific inhibitor that induces apoptosis in a phenotypically identical fashion to MCL-1 siRNA.27, 28, 32 Herein, we have used A-1210477 and other selective BCL-2 family inhibitors to define the contributions of MCL-1, BCL-2 and BCL-XL in maintaining the survival of various NHL cell lines.