C9orf72 and amyotrophic lateral sclerosis: As multimerization of C9orf72 HRE G-quadruplexes may exacerbate the formation of RNA foci and cause neuron-toxicity in ALS/FTD15, disruption of these foci by targeting C9orf72 HRE G-quadruplexes may have beneficial outcomes in the treatment of these diseases.