Our data revealed that in adjacent normal mucosa only 8 of 100 cases (about 8%) exhibited low staining (+ or −), while 92 high staining (+++ or ++) (Supplementary Figure 1); in CRC tissue 101 of the total 162 cases (about 62.3%) manifested a low signal; and even 50 of 62 (up to 80.6%) metastatic lesions showed an absent DAB2IP expression (Fig. 1D). The gene discussed is DAB2IP; the disease is colorectal carcinoma.