DAB2IP and neoplasm: To assess the significance of DAB2IP in CRC, we first performed an immunohistochemical (IHC) analysis, and found that DAB2IP was distinctly down-regulated in the CRC tissue in comparison with adjacent normal mucosa in the same slices (Fig. 1A), and also observed that expression of DAB2IP in the tumor invasive front was clearly lower than in the center region (Fig. 1B).