GCG and obesity due to melanocortin 4 receptor deficiency: This association is established because the concentrations of stress-related hormones (cortisol, epinephrine, noradrenaline and glucagon) increase during adverse conditions and acute or chronic hypersecretion of these substances can lead to metabolic disorders and inflammation.22 Stress also contributes to poor eating habits and lower levels of physical activity, both associated with overweight and obesity, which are risk factors for the development of cardiometabolic diseases.13