CD4+CD25+ cell numbers were negatively correlated with serum BUN, uric acid, supernatant IL-4, serum IL-6, urinary protein, bone marrow plasma cell percentages, blood monoclonal immunoglobulin and β2-microglobulin, but positively correlated with eGFR in MM-RI patients. This evidence concerns the gene IL6 and Miyoshi myopathy.