Moreover, we thought it is necessary to use another subgroup of patients with wild-type EGFR who had matched short and long PFS to verify reversely that the identified miRNAs in the first two groups contribute to primary resistance of EGFR 19 del NSCLC patients, but have no relation with resistance of EGFR wild-type NSCLC patients. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.