Using the recently described SET antagonist peptide, OP449, which has been reported to activate PP2A in multiple cancer cell types and inhibit relevant oncogenic pathways including c-Myc and Akt13, 17, 18, 19, 20, 21, we found that pharmacological inactivation of SET resulted in potent growth inhibition of enzalutamide resistant prostate cancers. Here, MYC is linked to prostate carcinoma.