miR-584 was shown to decrease cell motility through the inhibition of Rho-associated coiled-coil-containing protein kinase 1 (ROCK-1) in renal cell carcinoma (RCC) cell lines, and the expression of miR-584 was inversely correlated with that of ROCK-1 in RCC tissues [98]. The gene discussed is ROCK1; the disease is renal cell carcinoma.