Hypomethylation of phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a tumor suppressor gene, destabilizes the gene and results in the upregulation of the phosphatidylinositol 3-kinase/Akt kinase (PI3 K/Akt) pathway, which activates Akt, a protein that regulates anti-apoptotic proteins and cell cycle entry resulting in survival signaling [91]. This evidence concerns the gene AKT1 and neoplasm.