A recent study found that reactivation of hepatitis B following HBeAg seroconversion correlated significantly with genotype C (p = 0.003), male sex (p = 0.03), ALT levels >5× upper normal limit during the HBeAg-positive phase (p = 0.02), and age at HBeAg seroconversion ≥40 years (p = 0.002) [63]. This evidence concerns the gene GPT and hepatitis B virus infection.