In another study of 3233 Chinese patients with chronic HBV infection who were grouped on the basis of ALT at presentation and followed for 4 years, it was found that the group with ALT values that were one to two times the ULN (range of comparison 0.5–6 U/l times the ULN) was at highest risk of complications of cirrhosis and HCC. The gene discussed is GPT; the disease is hepatocellular carcinoma.