The proteinuria-lowering effects of synthetic ACTH were confirmed in further studies of the same group, with prolonged remission after a 2–11 months course of synthetic ACTH treatment in patients with several proteinuric diseases (iMN, Minimal Change Disease, Mesangioproliferative glomerulonephritis, Diabetic Nephropathy, Focal Segmental Sclerosis). Here, POMC is linked to lipoid nephrosis.