POMC and metabolic syndrome: [22] Other potential working mechanisms of ACTH are: activation of MCR1 on podocytes [23], anti-inflammatory actions in the kidney through MCR 2 interaction, direct MCR-mediated systemic immunomodulation and anti-inflammatory effects on peripheral blood leukocytes (MCR 1, 3 and 5), kidney protection secondary to correction of dyslipidemia mediated by the MCR on hepatic cells (MCR 1, 5) and renal protection via neurogenic anti-inflammatory effects mediated by MCR’s expressed in the central nervous system (MCR 3, 4).