Expanding our search to 10 kb, and focusing only on breast-cancer related transcription factors as targets (along the lines of the MYB-TAL1 gain), we found an additional 91 SNVs and 11 insertions with high impact (S4 Table), including a gain of TP53 CRM upstream of SOX5, and a loss of a SIX5 site upstream of NR3C1. Interestingly, these two latter insertions are recurrent across the TCGA cohort (39 and 59 samples, respectively). Here, SIX5 is linked to breast cancer.