However, when we trained a MYB-specific M1 model, using MYB target CRMs as training set (obtained by anti-MYB ChIP-seq in the Jurkat T-ALL cell line [6]), the TAL1 mutation yields a very high PRIME score (from 0.054 in the reference to 0.3774 in the mutated CRM). Here, MYB is linked to acute lymphoblastic leukemia.