In those mice that developed ECM on day 7 p.i., there was a further significant increase in numbers of perivascular pRBCs (∼22 pRBC/mm2), which represents a 10-fold increase that is substantially more than that of peripheral parasitaemia (1.5-fold increase), or adherent luminal pRBCs (no increase), observed between days 6 and 7 p.i. In contrast to LCMV encephalitis, another CD8+ T cell-dependent immunopathological model, we did not observe any evidence of petechial hemorrhages during intravital imaging of meninges of mice with ECM. Here, CD8A is linked to viral encephalitis.