NLRP3 and hyperuricemia: Although data in adult male rodents show that fructose exposure induced hyperuricemia, dyslipidemia leading to NLRP3 inflammasome activation [34, 35], it is likely that either sexually dimorphic effects (other studies have primarily been in males) or likely pregnancy-specific effects on fructose metabolism, as maternal metabolic adaptation to pregnancy results in different hepatic fuel utilization compared to adult male rodents.