Since obesity often precedes, and increases the risk of T2D, it will be of interest to investigate the development of changes in VGF peptide profiles in human obesity, as a potential clue to the their role/s in the development of T2D, and/or as a lead to the development of novel monitoring or therapeutic strategies aimed at controlling obesity and/or the evolution to overt T2D. The gene discussed is VGF; the disease is type 2 diabetes mellitus.