ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Due to the limited number of BCR-ABL+ cells within the most primitive hematopoietic cell compartments (Holyoake et al., 1999; Holyoake et al., 2001; Vargaftig et al., 2012), establishing technologies for de novo generation of LSC-like cells would provide a significant benefit to the CML field.