Consistent with in vitro LTC-IC studies, OLFM4 knockdown also abrogated the engraftment of BCR-ABL+ cells in NBSGW mice, thereby providing another critical evidence for the essential role of OLFM4 in homeostasis of CML cells in vivo. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.