CML originates in hematopoietic stem cells (HSCs) with t(9;22)(q34;q11.2) translocation, which causes the constitutive expression of the BCR-ABL kinase driving the expansion of leukemic progeny (Holtz et al., 2002; Holyoake et al., 2001; Ramaraj et al., 2004). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.