These differences included the upregulation of genes associated with cancer development, such as BCL2, CDK6, PRKCQ, MYCN, CDKNA2A, GFI1B, TP53RK, and RASGRP3, and the downregulation of adhesion molecules ICAM1, ICAM3, ITGB2 and ITGB7 (Supplementary Fig. S3b and Supplementary Table S1). The gene discussed is ITGB2; the disease is cancer.