They found that gene signature profiles of Th2 (IL-13, IL-4) and Th17 (CXCL1, CXCL2, CXCL3, IL-8, CSF3) immune responses were inversely correlated in these samples suggesting a reciprocal regulation of these two pathways in asthma [41]. This evidence concerns the gene CXCL2 and asthma.