These studies largely concluded that ID in obesity is likely due to hepcidin-mediated reduction in iron absorption and/or sequestration, and that increased serum hepcidin levels may be due in part to subcutaneous and visceral adipose tissue secretion of the protein as well as increased liver hepcidin production and secretion mediated by inflammation [14,32]. The gene discussed is HAMP; the disease is obesity due to melanocortin 4 receptor deficiency.