VEGFA and neoplasm: Many tumors are also infiltrated with mature myeloid cells such as M2 macrophages since monocytes entering the tumor adapt to the environment consisting of IL4, IL13, IL10, and TGFβ by differentiation into M2 macrophages secreting even more TGFβ, IL6, IL10, VEGF but also other factors such as IL17, IL23, fibroblast growth factor 2 (FGF2), a number of chemokines and matrix metalloproteases (MMPs) [18].