While higher expression levels of TRiC have been associated with tumorigenesis, a recent analysis of cancer cell lines appeared to show less correlation between TRiC concentrations and its specific activity The disparity between TRiC concentrations and TRiC activity has been attributed to the dynamic partitioning of substrates between TRiC, its co-chaperones, and HSPs that seems to be influenced by concentrations of HSP70 within the cell [8,17]. Here, MARVELD2 is linked to cancer.