DGCR6, duplicated in five patients affected by CL, CLP and CP (Supplementary Tables 3, 6), has been proposed in literature to be involved in the developmental defects associated with 22q11.2 deletions syndrome (aka DiGeorge syndrome) (OMIM*601279) (Demczuk et al. 1996; Das Chakraborty et al. 2012). This evidence concerns the gene DGCR6 and 22q11.2 deletion syndrome.