Many studies have confirmed the contribution of SATB2 to CP both in non-syndromic and syndromic forms, causing Glass syndrome (OMIM #612313), Pierre-Robin sequence with or without ankyloglossia and cleft-associated intellectual disability (Supplementary Table 2) (FitzPatrick et al. 2003; Beaty et al. 2006; Britanova et al. 2006; Dobreva et al. 2006; Leoyklang et al. 2007; Rainger et al. 2014). This evidence concerns the gene SATB2 and ankyloglossia.