SPRY2 and Legius syndrome: SPRED1, recognized as the causative gene for Legius syndrome (OMIM #611431), interacts with SPRY2 that has been described as a causative OFC gene (Supplementary Table 2) (Vieira et al. 2005; Goodnough et al. 2007; Welsh et al. 2007; Spurlock et al. 2009; Matsumura et al. 2011; Song et al. 2015).