Moreover, mice treated with si-A20 and si-A20′ showed a significant increase in CD4+IFN-γ+ and CD8+IFN-γ+ T cells compared with that in control groups, which indicated that the increase in cytotoxic T lymphocytes (CTL) might also contribute to tumor regression (Fig. 4a,b and Supplementary Figure S4a and b). The gene discussed is CD4; the disease is neoplasm.